Video Transcription:
Hey everybody Dr Sean Talbott here I’m going to uh give a product overview um but I’m this is uh this is specifically for health professionals and so what I’m going to do is I’m not going to talk about every single product in the Pro in the Amari product line.
I’ve done that on another presentation you can go you can go look at that, that one is kind of 30,000-foot view where I have basically one slide for each product and I sort of give the highlights. What I want to do here is talk about half a dozen or so of our of our leading products and really get into the nitty-gritty of some of the science because I think as health professionals, you’ll appreciate some of the stuff that we’ve done.
So I wanted I want to try to do a little bit of that so without background further ado let’s jump into this. A little bit about my background, I’m trained in nutritional biochemistry that’s what my PhD is in from Rutgersum, and uh for the first part of my career I was what you might call a sport nutritionist right, trying to use nutrition to change biochemistry to get the best performance out of elite level athletes.
So I did a lot of work with Olympic training centers and U.S ski team and U.S track and field Association, and you know it was a great great thing right, what we were trying to do is use food and nutrition and Sleep Quality and um and biochemistry and stress hormones, and proper recovery so that these athletes could get an edge. And sometimes that was a mental Edge we were trying to get for them so that they could get the best out of their physical performance, and you know great thing to do, uh shifted gears though and really trying to take those same principles and apply them to a mainstream audience.
So that let you the average person that feels just kind of blah can feel amazing again, the first person who feels terrible can feel normal again the person who feels great can get that mental Edge, and they can ,you know and they can go and they can have better resilience and they can handle more stress and they can get more done.
And that not what I just described is what I refer to as the mental Wellness Continuum, where you might have some people that are you know a little depressed, a little anxious, a little burned out you know that kind of thing, they’re not diagnosed necessarily with anything but they they feel terrible and positive psychology refer to them as languishing or sometimes refer to them as as having burnout.
Um those people, the objective is to try to get them to feel normal again. The big part of the population are people that we see all the time who just feel kind of blah, they feel fatigued in the day, they feel anxious and Restless at night. They don’t get a good sleep quality they just feel kind of blah. They’re kind of dragging themselves through all the time, they don’t feel great.
Those people we want to get feeling amazing right, we want to take them from being a on a scale of one to ten on that mental Wellness Continuum, they might be a five and our objective is to get them to be a seven because once they get to be a seven then they want to be an eight, once they get to be an eight they get to be a nine. The high-performers that might already be a nine they definitely want to try to get to be a 10 right, they’re interested in you know, getting that edge right.
How can I be a 9.1 or a 9.2 or a 9.3 those are the Elite athletes that I used to work with and that what I just described these days is referred to as nutritional psychology, the idea of using nutrition and using supplements which I’m going to talk mostly about tonight. Using supplements to to optimize that performance, optimize that mental performance whether it’s their mood or their focus, or their resilience or their stress levels, or their ability to relax and get a good night’s sleep, or whatever right.
Understanding The Second & Third Brain
All of that falls under the mental Wellness umbrella and it falls under the Mentalist umbrella, based on this new paradigm that how you feel is not just in your head, it’s also in your gut. What we call the second brain, which is the source of most of our neurotransmitters, and it also comes from the third brain, our heart. Which is the source of a lot of electrical signals and electromagnetic signals, which can influence our brain waves.
So that new paradigm of the microbiome which is part of the gut, we’re going to talk about that in a second, and the gut and the heart and the brain and the axis in between, which we’re going to talk about, those are all tools that we have available to us to optimize or improve the function of, or modulate the efficiency of, and in doing so we can help people feel better.
So this kind of stuff I’m recording this right now, I’m going to post it on YouTube it’s going to go up on Facebook, it’s going to go on the amari.com website. We’re going to put it in a lot of different places, you can see up here all the different places that we put information, um Facebook pages amari.com I have a YouTube page Instagram page, my blog is usually a really good place to go to get uh you know research articles that I’m commenting on and things like that.
And I also have this, this is an organization called any question where you can you can sign up for my section, you can ask me any questions there and it gets posted to any question, it also gets posted to Instagram, you can download it and use it on your own social medias but, um what we’re talking about here is this Paradigm of the gut being good at certain things, the head being good at certain things, the heart being good at certain things, and what you don’t see on this slide, you’ll see on it you’ll actually see in a couple of slides, the axis which is your immune system and your endocannabinoid system, and your nervous system.
These are all Targets that we can naturally modify to improve how somebody feels and how somebody performs, and a lot of times we do that through supplements. But before I get into supplements, I want to sort of frame for you where I think where supplements fit.
Mental Fitness – The Sense Program
The Sense Program can be a very very important piece of an overall puzzle but they are not the only piece of an overall puzzle, so what you see on the screen right now is what I have um, is what I call the sense program. So sense is something I’ve been using for years and years and years, it appeared in my very first book, the book that you saw on the on the screen just a second ago.
Mental Fitness, that’s my 14th book so I’ve been writing about this for a good long time, um sense is this idea of describing to people that supplements can be the first piece of the puzzle, if they’re properly formulated, if they’re science-based, if they use the right amounts of the right kinds of ingredients, with the right extracts. We’re going to get into all of this uh, in the seminar tonight, but if those supplements are properly formulated and they can increase somebody’s motivation and their energy, maybe that person now is going to be more likely to be physically active.
Maybe they’re more likely to be an exercise, or maybe they’re more likely to get off the couch, where as before they were just too tired. Um maybe if we can use a supplement that’s properly formulated to control appetite, control craving, reduce stress eating that kind of stuff. Maybe now that person has the bandwidth so to speak, to choose a more prudent diet, and instead of going through the fast food drive-through, or picking up junk food, or just grabbing a you know, processed food, maybe they’re going to choose a salad instead.
The Importance Of A Good Night’s Sleep
If you can use a properly formulated supplement to help somebody relax and take the edge off, and calm the buzzing in their brain so that they can they can calm down enough, maybe they’ll get a better night’s sleep. And then that starts that whole positive Cascade of a good night’s sleep, it gives you a good day, a good day sets you up for a good night’s sleep, so the supplements can be, and if they’re used the right way, can be the first piece of the puzzle to help our clients and our patients get on the plan, that they already know that they need to be on right.
There’s a big gap between what we know, everybody knows they’re supposed to eat right, everybody knows they need more fruits and vegetables, everybody knows they need eight hours of sleep, everybody knows they’re supposed to be physically active. The gap between that what we know, and what we actually do are Behavior. Supplements can sometimes help us close that gap, but it’s really important for us as health professionals to educate.
Educate the people we work with to say hey, the supplements are a piece of that overall program, it’s not like you take the supplements and you know, swallow the pill and mix up the powder or whatever the case may be, and and sit back and wait for all the all the magic to happen right. They’ll get some benefits. Right then I’ll show you some data that shows that, but if we can use them to facilitate those other healthy lifestyle choices, I think that’s what we all are looking for, for our clients.
Products Programs – Mental Wellness Retreat
So a lot of times products programs here tomorrow, what we talk about is products, which I’ll mostly focus on tonight, programs, um well products programs in people and the programs are things like this is uh, this is our mental Wellness Retreat. This is a bed-and-breakfast-style mental Wellness Retreat, and I’m doing that presentation for you from here. It’s in Plymouth Massachusetts,
We’ll bring people in sort of retreat style, and we feed them healthy foods, and we expose them to Nature, and we take them out on the ocean, and we go to the beach and we go whale watching, and we do uh, we do a sound bath and we you know, we do all this all this kind of stuff. Mental Wellness modalities vagus nerve activation and red light therapy, and float beds and massage chairs and all that kind of stuff, to really surround people with all these program dramatic sorts of things.
Yoga breath work mindfulness Etc, so that when they go home from our place they’ve experienced a program so that they know how to do it themselves right, so they know that they can plug that into their own life and they can eat a little bit better. They can sleep a little bit better, we talk a lot about sleep hygiene here and we show people how to do that, but then people can apply those programs to their life and get benefits out of that. They can apply the products to their life and get benefits out of that, and the way that we distribute these products is direct to Consumer right.
You can buy the products on the website you, can buy the products from your Healthcare practitioner, you can buy them from your neighbor down the street right, people build businesses around this that’s the social networking social marketing aspect of how Amare does its business model. That’s the people piece of it you know, so we’ll do meetings all around the country all, around the world now, um and that idea of people needing social connections, people helping other people is a really really cool thing.
For example, we have a pilot program underway right now to help people lose weight after the holidays, you know after the first part of the Year everybody wants to get back in shape. And we’ve got several thousand people in this Facebook group and you know I’m helping moderate some of it. We’ve got other nutritionists and mental Wellness counselors that are moderating part of it, but a lot of the moderation, a lot of the support comes from the other participants right so the more that we can bring people totogether to help one another and learn from each other sort of the wisdom of the crowd if you will, that’s away to improve mental well-being.
Right so we can do it with products, we can do it with programs, we can do it with people and what we’re trying to do here tomorrow is bring all of that under the same umbrella so that it’s a it’s a One-Stop shop you know, in a certain sense. And the cool thing about it is that, that One-Stop shop is not going to be the same stop for every single person. So my program of products programs people, is going to be really really different than Joe’s then Jane’s then gyms, then you guys get the idea.
Hearts & Mindstalking – The Link Between Physical Health & Mental Health
And that’s how we can customize these regimens and that’s exactly what I talked about in this keynote Heart Minds presentation that I just gave at this joint Conference of Nami National Alliance for mental illness, and mha Mental Health America. So I gave the keynote here at the conference called Hearts and Mindstalking about the linkage between physical health and mental health, and it was really really cool because what I talked about was the microbiome gut brain-heart axis, and how it’s related to mental well-being.
So I talked a lot about the microbiome, I talked a lot about different probiotic strains and prebiotic fibers, and what we call phytobiotics, plant extracts or phytonutrients that can change the signaling across the gut brain Axis or the heart brain axis, and I gotta tell you it was really really well received, because people in Nami and people in mha tend to be very sort of brain oriented, right they want to talk a lot about talk therapy and mindfulness and cognitive behavioral therapies.
Those can all be wonderful tools for certain people but now we have to broaden our view and say yep that’s one way to do it. Supplements are one way to do it, probiotics are one way to do it, uh mindfulness is one way to do it uh, breath work is one way to do it, physical activity is one way to do it good sleep quality is one way to do it.
You guys get the idea right, we’re in the point now where the science is giving us really really good really evidence-based tools that we can bring to bear on this problem and customize whatever regimen is going to be the right thing for the people that we’re working with.
Okay so let’s start getting into some of this um, so we do a lot of research here Patents um and because we do a lot of research we find things right, we discover very interesting things and that leads to an intellectual property platform, meaning we have lots of scientific presentations that we do at different scientific conferences. Lots of peer-reviewed Publications.
I’m going to share the datafrom some of those as we go through tonight we have lots of patent applications, so patents protect the invention of a new formula that does a new thing that was not previously known or that was you know never described before. And so we’ve got dozens of patents pending globally and we’ve actually just been awarded two of them, two more to come uh, in the next couple of weeks but I won’t talk about those right now.
Mental Heart & Kids Mood Products
Um mental heart which is one of the products that I’ll talk about in this presentation and kids mood plus another product that I’ll talk about in this presentation were just awarded uh United States patents and so the reason that I mentioned that is because it’s one thing for me as the chief science officer of this company and the formulator of most of these products, to say these are great products right, you know you’re going to love them they’re the best thing out there right. They’re the greatest thing since sliced bread.
I’m obviously a biased observer uh in that regard uh, so it’s you know it’s one thing for me to say it, it’s another thing for it to be presented at a peer-reviewed scientific conference and then published in a peer-reviewed scientific publication, and then patented by the U.S patent office. These are all different levels of sort of like stamp of approval or thumbs up or however you want to describe that. We also have multiple best of awards across the industry so sometimes it’s for the company like our company MRE has been a voted startup of the Year twice.
We’re no longer a startup but you know that was good in those growth years um we’re still like growing like crazy, but we’re definitely not a start-up anymore. We have a number of uh best product of the year you know, probiotic of the year, Botanical of the year product of the year you know etc etc. So I’ll mention those for the couple of products that I’m gonna talk about but they many of them come back to this idea.
Not all of them right because think about Microbiome ,sometimes we’re working in the brain in the head, sometimes we’re working in the brain in the heart, sometimes we’re working in the brain in the gut, and in the brain in the gut, sometimes we’re working on gut Integrity, reducing leaky-gut. Right the actual tissue of the gut sometimes, we’re working on the environment of the gut, making sure it’s just slightly acidic which is what good bacteria like to live in.
Bad bacteria don’t don’t necessarily like to live in and sometimes we’re talking about the actual bacteria which is the microbiome and so the microbiome research right, any health professional watching right now probably has a at least an exposure to the microbiome without exaggeration. What we’re learning about the microbiome is changing how we think about mental wellness, it’s changing how we think about physical health, it’s changing how we think about all of Human Health and Longevity.
It really is completely changing the game and every week you know a ground breaking paper comes out around the microbiome’s involvement in, and you fill in the blank with whatever disease you want to say or whatever health condition or whatever Wellness trajectory right, it really is determining in large part what goes on in the rest of the body, and so here tomorrow we are really focused on the microbiome from the perspective of mental well-being in that.
Microbiome Signaling Molecules – Can They Really Affect Our Happiness?
I can sum it up in a couple of lines, if your microbiome is in Balance you’re going to feel good and if it’s out of balance you might feel not good in a variety of different ways. You might if your microbiome is out of balance right, sort of like very broadly, you don’t have enough good bacteria you have too many bad bacteria, and if you don’t have enough good bacteria they’re not producing the signaling molecules that you want.
Ninety percent of our serotonin comes from our microbiome the neurotransmitter, sort of being happy or sad. The about 70 percent of our dopamine associated with motivation comes from our microbiome, about 50 percent of our Gaba, the body’s primary relaxing neurotransmitter comes from your gut, um so you know if your gut is not where it needs to be, or if you don’t have enough good bacteria you’re not making enough serotonin, so you’re likely to be sad.
You’re not making enough dopamine you’re likely to be unmotivated, you’re not making enough Gaba you’re likely to be stressed and agitated and irritable and, then we haven’t even got into short chain fatty acids and all the wonderful things that your microbiome can make.
Or if you have too many of the bad bacteria that are making other kinds of signaling molecules like inflammatory cytokines, or you know immune activators in different ways right, it can really set the signals that are coming out of your gut and going across your axis up to your brain, and it you know introduce a lot of static into the system.
So if you’re out of balance you might be fatigued you might be sad you might be tense, you might be hungry, you can see the whole list there and years ago, 20 years ago we used to think that if somebody was fatigued that was one problem that needed one sort of an intervention in order to bring their energy level back, and then if they were sad that was a different problem that needed a different intervention to bring their mood back and etc etc.
Now we know that again in large part it’s their microbiome being out of balance so if we can rebalance the microbiome that brings their energy levels back and it brings their mood back and it brings their ability to relax back and it helps control their their hunger, and their appetite and their stress eating and those sorts of things it’s like this this is how I describe it to a lot of people, is that if your microbiome is in Balance it’s like having an internal on-demand Dynamic natural Pharmacy that makes what you need in the right amounts when you need it.
Right so that’s the idea of making enough serotonin so you’re happy and making enough dopamine so you’re motivated and making sure those signals traverse the axis and do get to the parade so we know that this happens, we know that we can give specific strains of bacteria that increase serotonin and dial down cortisol for example. And when we do that people feel less stressed they feel calmer they feel happier right.
We can quantify that kind of stuff in the in the clinicals and I’m going to show you how we do those measurements so the microbiome is a really really important piece of this overall puzzle. It’s not the only piece but it’s a very important piece of the puzzle and you’ll see sort of how we harness that in just a second.
The Heart Gut & Brain Axis
We also have to think about the axis you know when I say gut-brain Axis or heart-brain axis a lot of times people think that this axis word is just kind of a throw-away term, but it really is referring to another set of targets. The axis is sort of broadly the way that these brains communicate with each other. The axis is the communication Network and so the nervous system is part of that, some of the signals are hardwired signals that go from the gut through the vagus nerve for example, up to the brain and vice versa right.
It’s a two-way street or it’s a multi-way street actually, so things that happen in the gut can in a millisecond be transmitted to the brain across the vagus nerve. We can activate our vagus nerve with breathing because the vagus nerve also innervates the lungs so, if we’re doing deep breathing exercises that can help calm the brain it can also help calm the gut, it can also help us sort of shift out of fight or flight reaction.
The sympathetic nervous system into the parasympathetic activation which is more sort of the rest and digest, I’ll talk about that in a little bit, mostly as it relates to the heart-brain axis, but any of these we can adjust. There’s things we can do in the nervous system like I just explained vagus nerve activation, there’s things we can do in the immune system called immune system priming that can not only strengthen the immune system, it’s different from stimulating the immune system.
If we Prime the immune system your immune system is a better Shield so we know that people have you know fewer upper respiratory tract complaints if we have a primed immune system, versus not um but when your immune system is primed it’s able to send signals across the axis from your second brain to your first brain much more efficiently, and as a result of that we see about a 20 percent improvement in a psychological parameter called Vigor.
Which is one part uh physical energy one part mental acuity one part emotional well-being all wrapped up into one. That’s Vigor it’s the opposite of psychological burnout, we can improve that just by improving what the immune system is doing so there’s all kinds of things that we can do here.
The gut obviously I mentioned a little bit of that already and the endocannabinoid system there’s ways that we can activate your body’s endocannabinoid system to reduce pain and help with tension and help with Sleep Quality, and help with stress levels, and you know it’s really really exciting all the tools that we have now that we almost knew nothing about as little as a decade ago and this whole idea of the gut-brain axis.
Like I said Gut Brain Axis at the very very top of this call is fundamentally changing how we think about all of human health and that’s important because a lot of the things that you see here, these sort of syndromey kinds of symptoms that our clients and our patients complain about right, modern lifestyle issues um are there are the hardest to get a handle on, and it for so long problem has been treatments on offer as treatments have not been very effective right, antidepressants don’t work very well for the majority of people who take them.
Same thing with anti-anxiety drugs same thing with sleep drugs, same thing with ADHD medications same thing, but the things that people self-medicate with you know coffee and energy drinks and stimulants to get them up for the day and then depressants like you know, like alcohol for example to get people down in the evening right, these are things that are not on the target.
I guess but they’re definitely not on the bullseye because none of these solutions that have been on offer whether they’re pharmaceutical Solutions or junk food Solutions or whatever the case may be, um they are certainly changing how we feel but they’re not making us feel better they’re not making us feel good, they’re not making us feel happier or energetic or more vigorous, and any of that kind of stuff.
The reason for it is they’re not hitting the bullseye they’re not addressing the microbiome or the gut Integrity or the signaling across the Axis or inflammatory balance for that matter right. So there’s all kinds of layers across the gut brain axis that we can Target to help people feel better and I’ll show you what that looks like in just a little bit.
Identifying How Bad Microbiomes Can Affect Our Behaviour & Wellbeing
So before I get into that I just want to have a little bit of fun, how do we even know that the microbiome is all involved with all this kind of stuff, how do we know that? It’s not just that uh you know somebody who’s sad is eating a bad diet and because they’re eating a bad diet that’s giving them a bad microbiome right? How do we know that is the microbiome that is driving these psychological changes? Well Fecal microbiome transplants that’s how.
About a decade ago we learned this through what are called fecal microbiome transplants in rodents and now fecal microbiome transplants are being done in humans, uh to see you know to see the effects in a lot of clinical situations. So here we can take the microbiome from excuse me, from an obese Mouse and put it into a lean Mouse genetically identical mice.
The only difference that they have now is their microbiomes, obese microbiome into a lean mouse, that lean Mouse now becomes obese. Doesn’t just take on the metabolism of an obese Mouse, such as you know, they’re they become insulin insensitive their blood sugar levels fluctuate a lot their appetite hormones change. But they develop the whole behavior of an obese Mouse.
So they’re eating all the food they can get their hands on they’re stealing food from their litter mates they don’t get on the wheel and run anymore. They just want to sit in the corner so their physical activity patterns change their psychology around foods change, their behavior like their repetitive Drive changes. Everything changes.
But it goes back the other way. You can take the microbiome from a lean Mouse put it into an obese Mouse, and the obese Mouse loses weight and becomes more physically active and loses interest in the mouse version of junk food and etc etc. So that is really really interesting that you can change metabolism, you can change behavior, just with the microbiome switch
You can also do it purely with uh with behavior so here’s an example of, you can take a microbiome from an introverted Mouse, the kind of mouse that likes to you know, uh it likes to hide in this in the corner of the cage, it’s not very social with its litter mates it doesn’t get on the wheel and run it doesn’t like to explore outside of the covered areas of that little housing unit, it doesn’t go in the Maze, you know all that kind of stuff.
You can take that introverted microbiome or the microbiome from an introverted Mouse, put it into an extroverted Mouse, the mouse that’s on the wheel on the mouse that’s playing with his litter mates and the mouse that’s exploring every nook and cranny of the mouse condoum and it’s behavior changes, it becomes an introvert but again it can go back the other way, you can switch those microbiomes and switch the behaviors and when this work came out it was really really interesting.
But there was still the question mark of well wait a minute these are genetically identical inbred mice and that could never happen in humans right, these wonderfully complex humans were way different than that and yet, we can see studies like this with, there you can take the microbiome from a depressed human, these are two different groups two different cohorts, major depressive disorder and a control non-depressed. And you can just see looking at what without getting into the discussion of what all these different bacterial uh measurements, microbio memeasurements mean, you can see that just by a pattern difference the the pattern of microbiome in a major depressed subject, is different than a a non-depressed subject.
You can see it here you can also see it here the red dots are the major depression the blue dots are the are the control, so you can take a microbiome from a person. A human with major depressive disorder and put it into a normal Mouse and that Mouse develops depressive-like behaviors. We can never truly tell if the mouse is quote unquote, depressed but it’s certainly exhibits depression.
It doesn’t want to eat it sits in the corner of a cage it loses interest in you know, playing with a ball you know things that it used to like to do before. It really looks like it’s depressed right and we can transmit that emotion that psychology, we can transmit it through the microbiome. So with all of that as sort of a lead up the question, becomes well great that’s all very interesting science how do we take that science and how do we apply it to a normal situation where somebody wants to improve their mood or improve their motivation or improve their mental focus or bring back their Vigor, or you know any of the kinds of things that we can measure from a psychological standpoint?
The Gut-Brain Fundamental Pack
How do we do that? So the first way that we did Gut-Brain Access. That our original flagship product was the world’s first gut-brain axis system called the fundamentals pack. So in that pack is three different products, one for the gut one for the brain, and one for the axis in between.
So the one for the guts called mentibiotics the one for the brain is called mentalfocus and the one for the axis is called mentosync and so you can buy those products separately and people do um, you can use them separately and it and I always do this, I say that if you were to use any one of these products separately or any of the products I’m going to talk about separately you would quote unquote feel better right, and what I mean by that is feel better means that if you took just metabiotics you would feel better.
But the feeling that you would get would more be along the lines of lowering your tension lowering your stress raising your resilience right, mental focus is also going to help you feel better but that’s going to be more around mental Clarity and memory. And if your brain is working better you’re going to feel better in that way. Mentosync improves Vigor by about 20 because it works primarily on your immune system to prime your immune system and help you send signals more efficiently across that part of your gut-brain axis.
So you’ll feel better with mentosync in those ways you’ll feel better with metabiotics in those ways you’ll feel better with mental focus in those ways, and so we decided we would put it all together in one pack, gut-brain access and when we launched it in 2018 we won this award called the Nutra award which is given once a year to one company with one product that represents the best new finished product in the entire industry. So 2018 we won that and the reason we won it was the microbiome research had just gotten to the point where we felt it was ready for prime time, that you you could harness it and you could build it into something that somebody could apply in their life.
What we mean by that is that IT addresses each of the levels across the gut-brain axis that potentially could be out of balance because the challenge with mood State research is that people know when they feel crummy they just don’t necessarily know why they feel crummy right?
In fact that’s the number one reason that people will come to see any of us who are watching this video right now right, their energy is low they have some brain fog they’re not motivated they’re not necessarily depressed, they’re not necessarily anxious they’re that person with languishing that I said before um or you know they just feel kind of blah and that blah might be because their neurotransmitters are off, and if that’s it we can solve that we can solve that in the brain there’s all kinds of ways we can change neurotransmitter balance.
We can give them pine bark extract we can give them pomegranate extract we can increase blood flow to their brain with you know, nitrate enhancers like like noni or pomegranate or beetroot. There’s a lot of ways we can solve that problem. Nootropics for example we’re going to talk about those in this presentation, but what if it’s not the neurotransmitters that are out of balance what if it’s something that’s blocking the neurotransmitters like inflammation?
Maybe they’re over-inflamed and we need to get rid of the inflammation so that their neurotransmitters will work more efficiently. Well we have a way that we you know, in this pack that solves inflammation we can also ask the question next of well wait a minute where is that inflammation coming from in the first place? It might be because their immune system is overactive or agitated or um or just disrupted, so if we Prime the immune system we get the immune system in Balance.
If the immune system is balanced we remove a big source of inflammation, if we remove that inflammation then there are neurotransmitters work better so you get the idea. We go all the way down.
Identifying The Correct Strains Of Probiotic Bacteria To Improve Leaky Gut, Improve Mood, Lower Tension & More
One of the things that can set the immune system off is leaky gut. So we improve gut Integrity, make sure that the gut is not permeable or semi-permeable the way it’s supposed to be and maybe the gut is out of balance and you have that leaky gut because your microbiome is out of balance and maybe if your microbiome is out of balance you’re not making the good neurotransmitters, and you’re making too many of the inflammatory cytokines right.
So any of those or all of those could be out of balance and that’s why fundamentals pack is so impactful in so many different ways for so many different people, and I’m going to explain a little bit about what’s in it, like how we get those benefits, but basically it’s this, that we use specific strains of probiotic bacteria that have been clinically validated to improve mood, improve tension improve stress.
Then we partner those up with Prebiotic fibers, specific structures of Prebiotic fibers that these bacterial strains will use to do their job and those fibers will reduce stress and improve resilience. We also have a whole range across these three products of phytonutrients, what we call phytobiotics plant extracts. These phytobiotics are actually patent pending right now for the effect of of improving Mood by enhancing signaling across the axis portion of the gut brain axis, and those would be things like theanine and pine bark and apple polyphenols an grape seed polyphenols.
There’s a whole range in them we can bring to bear on the problem and so you know once we do all of that then we do research and we publish these thes studies in peer-reviewed scientific Publications and scientific presentations so you know we’ve got it. We’ve got another slide deck or where you’ll have all the different research um links that you can click on and so whoever shared this with you, you can ask them for that it’s a separate one there’s one of them there I’m going to refer to a few of them as I go through here.
We have one document that has all of them in there and we update that from time to time as we need to. So when I say probiotics it’s really really important to get Probiotics across, this idea which is something called probiotic strain specificity and if there’s one concept that you take away from this entire hour and a half or so that we’re going to be together it’s this probiotic strain specificity and what this means is that specific strains of bacteria have specific benefits.
Said the other way specific benefits are delivered by specific strains of bacteria and if you don’t know the strain you have no idea what it’s supposed to do, none. You don’t know it well you don’t know anything about it, you don’t know what benefit it’s supposed to give you, you don’t know how many of them, how many Colony forming units you need to take you don’t know is it susceptible to stomach acid.
You don’t know if it’s susceptible to temperature do you have to keep it cold or can it be you know, stored at room temperature, you don’t know anything about it so if you only knew lactobacillus ramnosis you could not tell me what it’s going to do you have to know this last part which is the Strand designation so probiotic nomenclature is that this is the genus, this is the species, this is the strain and I would say even to this day 90 of the products on the market do not tell you the strain designation and again if you don’t know the strain you don’t know what it’s supposed to do.
Here’s an example, this is lactobacillus ramnosis r0011 this strain designation tells me that this is a stress-reducing strain of bacteria, we know the mechanism is that it lowers cortisol and it raises Gaba so lowering cortisol is going to help people be less stressed, you’re turning down a negative signal and raising Gaba you’re turning up a good signal. It’s going to help people to be more relaxed so less stressed and more relaxed with the same bacteria that’s why we can say that this is a stress-reducing bacteria.
Here’s an example of strain specificity, there’s another lactobacillus ramnosis that we use in another product called um strand designation is lr32 that one helps with gut motility meaning it can help regulate the speed at which food moves through your gastrointestinal tract, so if you’re a little bit constipated it can help you go to the bathroom, if you have a little bit of diarrhea it can help slow down you going to the bathroom right. So motility enhancement right it can it can speed up or slow down.
There’s another strain that’s in every grocery store in America it’s a product called Culturelle, very good product it uses a strain called Lactobacillus ramnosis GG is the strain designation, that one is really good for travelers diarrhea it also helps a little bit with the immune system so if that’s your problem, by all means, go get that one.
There’s another strain that we might use in the future it helps with vaginal yeast infections it’s called lactobacillus ramnosis, gr1 is the strain designation, wonderful for women who have recurrent vaginal yeast infections right, take that for a week or so yeast infections get all cleared up. But think about that so lactobacillus ramnosis I just talked about r0011 as the anti-stress one lg30 or l32 lr32 as the um, as the motility constipation or diarrhea GG is the traveler’s diarrhea gr1 as the yeast infection right, all those different benefits all from just a different strain designation so it’s really really important that you know the strain.
I actually can’t recommend to products that don’t have a strain designation because it’s a total crapshoot right, I say to people all thetime if you pick up a bottle and you see oh it’s got five different bacteria and it’s 50 billion and it’s on sale and it’s all these good reasons to choose it, if you don’t know the strain designation you might as well just close your eyes and reach up onto the shelf and grab any old one because it’s going to have the same level of effectiveness right.
You have to know the strain so and once you know the strain you know what the main benefit’s going to be you know it’s susceptibility to stomach acid and to temperature and you know what its shelf life is going to be and you know, do you have to supplement it at a billion cfus or 10 billion cfusor 50 billion cfus like you’ll know that based on the strain designation. So what we do here in this product, so this is these are the bacteria that we have in metabiotics which is part of fundamentals.
We have one strain that is good for reducing stress another strain that’s good for enhancing calmness and another strain that’s good for enhancing mood and the reason we did this is so that some one person could take that mentibiotics and they could feel better no matter what their problem was. A lot of times when you feel crummy like I was saying before you don’t necessarily know am I feeling crummy because of a serotonin mood issue or am I feeling crummy because more of a calmness feelings of anxiety sort of a thing.
A lot of times those are overlap or am I just stressed out you know and that’s leading to me feeling the way I’m feeling so our idea was let’s get people feeling more holistically better in all these different ways and we can do it with this combination. So these are the three strains that we use um of bacteria we don’t stop there though. The base of that mental biotics Prebiotics powder is a base of Prebiotic fiber, so prebiotics are the food that bacteria will use as their fuel source.
The reason we eat high fiber, a reason we’re supposed to eat high fiber foods isn’t for us, it’s for the bacteria, that’s their preferred fuel source and so you know eating more fiber is a good thing right, if you can get more whole grains and more brightly colored fruits and vegetables and all that kind of stuff Hallelujah. But these are targeted Prebiotic fibers is omaloligosaccharide and Imo galactooligosaccharide a goss and a galactomanc.
Those words in parentheses refer to the structure of the fiber and the structure of the fiber is indicative of what bacteria is going to preferentially want to eat, that as its fuel source not all bacteria eat all prebiotics and at least at the same efficiency right, they have of there are bacteria that prefer certain prebiotics or said the other way there are certain prebiotics that feed certain kinds of bacteria.
So the reason we chose these particular three there’s you know dozen or so prebiotics that we could choose um sometimes Prebiotic fibers um uh have a tendency to give people gas and bloating because when the bacteria start feeding on that fiber you produce like one of the um one of the end products of that fermentation is gas and so that can sometimes take a couple of days or a couple of weeks for people to get adapted to these are low gas producing prebiotics, but they’re also prebiotics that have been studied to show that they can increase resilience so the people eat these people supplement with these uh in the clinical trials, they’re microbiome diversity improves and I’ll show you what that looks like in just a second.
So more good bacteria grow the bad bacteria areas sort of die off because they sort of grow on processed foods and junk foods and sugars and things like that so you start eating more of these you grow more GoodGuys, the good guys displace the bad guys but they do it in a way that don’t produce gas but instead produce a lot of the uh happier signaling molecules. You know more of the serotonins and the dopamines and the gabas and the short chain fatty acids and things like that so that’s good you’re getting more of the bacteria right so you’re changing the structure of the microbiome but, you’re also changing the function of the microbiome in terms of the production of those signaling molecules, and then so you could feel better because you took the bacteria probiotics.
You could feel better because you took the fibers the prebiotics, but we also go the next level that most companies don’t and make sure that we have matched these up for that preferential metabolism so to speak that these fibers that we use are the ones that these bacteria want to use okay. So you know you can see something like an IMO feeds all the good bacteria the lactobacillus and the bifidobacterium whereas something like a Goss feeds primarily the bifidobacterium and we want both of those right.
We want the lactobacillus for certain reasons we want the bifrobacterium for certain reasons and that’s why it’s important for us to actually measure the microbiome in our clinical trials. So here’s one example of a study that we’ve done this was on our fundamentals pack where we just had people use it as recommended right here’s the pack, please you know we recruited people that were moderately stressed, we followed them for four weeks a month uh we said take the supplement as directed one serving a day we’re going to measure your microbiome at the beginning we’re going to measure your mood State at the beginning and then after the supplementation period of four weeks we’re going to measure you again and see what happens and we published the research here in functional foods and health and disease and here’s what we found.
30-Day Microbiome Clinical Trials Findings
We found that the microbiome was better right exactly what we would expect, we didn’t in this trial, we didn’t study people with depression we didn’t study with major depressive disorder we didn’t study people with generalized anxiety disorder we didn’t study people with diagnosed burnout or PTSD or anything like, that because those studies had already been done those Studies have been done on the individual ingredients.
We wanted to see what this pack would do out in the real world with those people who just feel stressed out and blah and sleep deprived right so that’s the population that people were going for and what we found was after after 30 days of supplementation their microbiome was better and we can measure how is it better, well lactobacillus went up 28 bifrobacterium went up 30 percent their overall composite score was 17 higher this is sort of an overall diversity overall resilience score which averages together the good guys the bad guys the ratios between the you know the different families of bacteria.
So on every parameter we looked at the microbiome was better um I mentioned on the last slide that lactose are good for certain reasons and bifidos are good for certain reasons we can look at that and we can see well all right um lactobacillus is good for making the environment of your gut just slightly acidic and that’s good for the bifidos because that’s the environment they want to see and if it’s a slightly acidic environment then more bifidos are going to grow, and if more bifidos grow and you give them the right Prebiotic fibers they’re going to produce more of those signaling molecules
The short chain fatty acids and the neurotransmitters and things like that and as a result of this microbiome looking better people felt better and this is what really really matters right I joke with people all the time nobody wakes up on the last day of one of our studies and says oh my bifidobacterium feels really good today right you don’t feel that you feel the result of having a good internal on-demand in demand like an internal on-demand natural Pharmacy.
You feel that in terms of your mood your tension is lower your depression score is lower your anger fatigue, confusion all your negative mood states are lower coming from a place of being moderately stressed change your microbiome all your negative mood States go down right.
You’re feeling less bad but you’re also feeling more good so this is vigor the opposite of vigor would have been burnout right so we could have put burn out here and had all negative mood States but the point that I want to really make here is that we can turn down a negative signal and somebody feels less bad and that’s a way of making them you know, improving how they feel or we can take a good signal and turn it up so amplify a good or de-emphasize a bad, and what we’re doing here with the microbiome is doing both of those simultaneously and that’s when people start to feel really really good.
The problem with antidepressants as I was talking about earlier is that they tend to just make you feel less bad right so they and a lot of times they make you feel less of anything and that’s why most people don’t like to be on them long term and a lot of people have trouble getting off of them after being on them long term. But if we can do both of those from the perspective of this Dynamic Pharmacy which is your microbiome that can help people feel normal again that can help people thrive, that can help people go yeah I’m back right and that’s a really really good thing that we can do for our patients and our clients.
I mentioned a little bit already about the mic about the specific bacteria that we’re talking about the um the probiotics right specific probiotic strains and you can see those here and I mentioned the specific strain or the specific umuh uh, Prebiotic fibers and here you’re only seeing two of them, you’re seeing uh bimino Goss and uh the sun fibergalactomanc um we’ve since uh reformulated that metabiotics product to have that third one in there. So you have three probiotics and three prebiotics with that IMO but then what you see for the rest of this chart this is taken right from one of our one of our research Publications.
You see in table one you see all of the phytonutrients right you see all the other things that we’re giving that will help that signaling process across the gut brain axis, so you see the ingredient you see its main purpose or effect and you see where it’s sourced from in the world right it really is a true Global Supply Chain. So some of these things are working in the brain some of these things are working in the axis, some of these things are working on the um on the Integrity of the gut the actual lining of the gut.
Some of them are working in inside other cells so it’s a lot and I say that and I show you the slide because if we want to get somebody to feel holistically better we have to think about the gut brain axis and the Heart brain axis as a system and we have to think about like what I said earlier, that how you feel is not just in your head it’s also in your gut it’s also in your heart it’s also in your immune system it’s also in your gut Integrity etc etc, because that’s what the science is showing us.
The science is showing us is that sure we can help somebody feel somewhat better by working in the brain we can help somebody feel some what better by working in the gut and somewhat better by working in the immune system, but once we put that all together that’s where they feel holistically better and that’s where we see mood State changes lik what I showed you on the last slide are, you know indexes are you know negative indexes are going down 50 percent positive indexes are coming up you know to 20 or 30 or 40 percent right.
Those are meaningful changes that can really get somebody to like function different in their life so like I said and I’ll say this over Research and over again we educate as much as we can about these ideas right so we talk about different strains we present our research at different conferences. This particular poster was one that was uh presented at the international Society for nutritional Psychiatry research an organization like this didn’t even exist probably five or six years ago um because nutritional psychology or nutritional Psychiatry wasn’t even a scientific discipline because we didn’thave the tools to measure this kind of stuff, um just a few short years ago and now we do so you know we’ve published it in peer-reviewed Publications.
We’re presented at longevity conferences that you know so this work is starting to get out there it’s starting to change how we think about mental wellness but then you know all of human health like I said before here’s another one of the studies that we did and this is an interesting study because remember when I said earlier that my perspective on supplements is that supplements can be the first piece of the puzzle in that sense Paradigm right? We can use the supplement to help somebody with their energy and motivation so they exercise more.
They know they’re supposed to exercise more we’ve all told them they need to exercise more or be more physically active and they don’t but if we can use a supplement to improve their energy levels and their motivation maybe they do that, if we can use a supplement to help with somebody’s appetite and their stress cravings and their Munchies then maybe they’re more likely to stay on the good diet that they know they’re supposed to be on.
It’s not that we need to educate people more about eating right and moving more and getting eight hours of sleep they know that and they’ve heard it a billion times from us and everybody else, but if we can help them to act on that more efficiently more effectively that could be a game changer and that’s what this study was, so in this trial what we wanted to do was do pretty much the same thing we did with that first trial, change the microbiome, change their mood but what we said in this trial to the subjects we said we’re just going to measure your biochemistry.
We’re going to take blood from you and we’re going to measure cholesterols and blood sugars and inflammatory markers we’re going to take your saliva we’re gonna measure stress hormones, we’re going to take your poop samples and we’re going to measure the microbiome we’re going to have you fill out all these surveys and we’re going to look at your stress and your mood and all that kind of stuff.
And so but we said to them please don’t change your diet patterns don’t change your exercise regimen don’t try sleeping more just go through your normal life for six weeks and we’re going to track you over time but what we’re actually looking at is the lifestyle behaviors right, so we’re looking at all of this.
Here are the results from the trial we found as we as we expected that good bacteria changed so lots more good bacteria bad bacteria went down there was a nice change in the ratios of different metabolic bacteria. I’ll show you that I’ll show you the graphs in a second all their metabolism change in a positive direction. Stress hormones went down blood sugar levels went down um cholesterols went down etc.
I’ll show you those data mood State changed all the negative mood States went down positive mood States went up but what we also found was that these people were choosing a better diet because we did a three day diet recall um that they would without trying to right it was a subconscious change we told them we instructed them to not change their diets and yet they couldn’t help themselves but eat a healthier diet, because they felt better they we gave them watch watches uh activity tracker watches Garmin vivosmarts that track their their stress levels and track their movements and track their step sand track their hours of sleep and minutes in REM and all that kind of stuff.
They slept better they moved more their Lifestyles were better while they were supplementing than they were before the supplementation even when we told them not to and the only thing we can conclude from that is that because they were feeling better in all these different ways they were more inclined to act on those healthy decisions, that they already knew that they needed to be making okay, so it was really really exciting thing to do which Data Slides which you know just dovetails with exactly how we think supplements should be used.
Anyway within the context of their overall healthy lifestyle pattern so here’s some of the data slides um these slides are all recorded So and posted so if you want to go and get the slides and really dig into the numbers uh you’re certainly welcome to do that if I if I go through these too quickly. So we looked at we looked at body weight and muscle mass they didn’t lose any um they didn’t lose any weight over time but they also didn’t lose any muscle mass over time.
This wasn’t a weight loss trial per se but they did lose about two percent um total body fat uh so that’s good so and that speaks to the fact that they were more physically active they were eating a better diet they were sleeping better over the course of those six weeks even though they weren’t on a fitness regimen so to speak right again because they were feeling better they were making good choices.
When we look at their microbiome we can see all of these positive changes, their overall composite score after six weeks was six percent improved which is a very significant very meaningful change um and then this composite score is made up of by averaging all of these different numbers plus some others so bifidobacterium went up one kind of good bacteria lactobacillus went up, another kind of good bacteria but good for different reasons like I described earlier.
Acromancia are really really important keystone species of bacteria that lives in the mucous lining of your gastrointestinal tract and as a signal if your acromancia is high that means you have a good mucous lining if you have a good mucous lining that generally means you have a good gut Integrity lining your enterocytes your actual tissue of your gut barrier function is strong usually if we see this low or we see it not abundantor we see it undetectable that that’s a signal that somebody has leaky gut so we saw 90 Improvement here so acromancy is not just a sigma for leaky gut or not and here it would show not after you know after a 90 increase.
But it’s also uh involved in metabolism it’s involved in mood State it’s involved in immune system regulation it’s involved in a lot of stuff so you want more acromancia so this is a really nice number for us to see this one that you can see going up 62 percent. I don’t know if you can see this behind my little video of me but this is um this is a strain called streptococcus thermophilus which is involved in your immune system regulation and so 62 percent uh Improvement there suggests a stronger immune system vigilance which is always going to be a good thing and stronger immune system.
If it’s properly primed like I was talking about before is associated with a higher level of vigor which is the opposite state of burnout so that suggests better resilience if your immune system is more uh more vigilant uh here’s figure 2B which is metabolism so with your metabolism one of the cool things we can look at from the perspective of the microbiome is a family of bacteria called firmicutes which are really good at harvesting calories from your food so when you eat a meal if you have a lot of firmicutes they’re going to be really good at getting the calories out of your food and into your body and store typically stored in your fat.
If you have a lot of bacteroides they’re less good at that so they will still Harvest calories but they’re less efficient at it so if you have a lot of firmicutes you’re more likely to be overweight if you have low bacteroides you’re more likely to be overweight and then if you have the double whammy high firmicutes and low bacteroides you’re very likely to be overweight or you’re very likely to be, have a tendency towards weight gain.
Let me say it that way so you could either lower pharmacies to reduce weight or raise bacteroides to reduce weight or prevent weight gain and we were able to show both of those so firmicutes went down a little bit bacteroides went up a little bit and this F to B ratio the ratio between good Harvesters and poor Harvesters is used as a metabolic Index right as a predisposition to obesity index if you will and so the reduction of 14 speaks to a very very nice metabolic benefit of the blend of um phytonutrients that we gave.
Here is a measurement called butyrate kinase so butyrate kinase is uh the Butyrate kinase enzyme that’s responsible for the production of short-chain fatty acids butyrate being one of those short-term fatty acids um so the fact that we saw an 89 increase here shows that the micro the entire microbiome has a much-improved capacity to make short chain fatty acids post supplementation than pre-supplementation and that’s good because of all the things I said before about short-chain fatty acids they’re nearly miraculous in terms of their biological effects.
They’re good for the brain they’re good for the immune system they’re good for your metabolism they’re good for your blood sugar control, they’re thought to maybe help to support mitochondria which is cellular energy production, they’re thought to support calorie burning fat burning in a type of fat called Brown fat they are miraculous little compounds that we don’t get enough of primarily because we don’t eat enough fiber short chain fatty acids come from the metabolism of fiber by the bacteria so here’s a way that we’re increasing butyrate or the potential for butyrate production.
The Machinery of butyrate production at the level of the microbiome with a supplementation regimen that is probiotics and prebiotics and phytobiotics cortisol levels went down cortisol being the primary stress hormone this is always a good thing to see 11 reduction of raw cortisol blood chemistries all went in the in the right direction so total cholesterol went down LDL bad cholesterol went down triglycerides went down glucose went down and really nicely.
Even though this wasn’t statistically significant this HDL good cholesterol did go up and that’s the reason I point this out is that typically the only thing that will really increase HDL is exercise and so it could be maybe that because these people were more motivated and were more physically active even though we asked them not to be um you know maybe that is that maybe that’s an exercise effect that we’re seeing there hard to kind of tease out because they uh they didn’t listen to us um and then uh cardiac risk profiles went down.
This is a ratio between total cholesterol and HDL good cholesterol so a seven percent drop in six weeks is actually a really really nice drop um so you know the numbers look the numbers look really really good overtime let me see why this isn’t changing there we go um this is looking at the profile of mood States so a lot of times when people know that we’re looking at mood they’re thinking that we’re just asking the subjects you know how are you feeling you know are you feeling less stressed are you feeling happier are you feeling more resilient.
We’re actually using a technique called profile of mood States p-o-m-s or short hand is Palms this is the most validated way it’s probably been used in three thousand four thousand different psychology studies over the years it’s the gold standard way to measure mood States in non-depressed non-anxious people I’m going to show you later in the presentation some other surveys that are used in studies of depression in studies of anxiety in studies of ADHD but this is not one.
This is a non-diagnostic tool but it’s really sensitive to interventions like this and so you can see depression index which is just a mood index it’s not measuring the disease depression confusion which is brain fog fatigue, anger or irritability tension are all these negative mood states are going down just like the first study that I showed you and then Vigor is going up just like the first study that I showed you um this is global mood state. Global mood state is sort of an overall average of all of these negative mood States and positive mood States subscales and this could be considered like an overall well-being index and on this particular parameter a lower number is a better number and you can see that Global well-being was 17 percent better.
Global mood state was uh was 17 better after that intervention and so that you know the sort of conclusion from this six-week trial the first one was a four-week trial this one was a six-week trial is that uh we that optimizing the gut brain axis improved both metabolism and enhance mental Wellness right so we saw all these metabolic parameters change we saw all these psychological parameters change and then we also saw all those uh behavioral parameters change because and this is our interpretation of it.
We use the supplements people felt better because they felt better they acted on making the better lifestyle choices because they felt better because their microbiome was better because they supplemented the right way, so that’s the sort of Moral of that story I wanted to I want to mention one thing real quick before I move off of the microbiome stuff for a second um and that is that that in my world right somebody who studies the microbiome studies mental Wellness what I just described is well known right when I describe this at scientific conferences other scientists who do this kind of same kind of work that I do go yeah well we’ve known this for five or six or seven years like this is well treaded.
Paths right it’s been repeated and repeated and repeated and we all understand this um it hasn’t flipped over certainly into the public domain right most people our clients and our customers and our patients don’t necessarily know that what you do in the gut is going to have an effect in the brain or the immune system or the cardiovascular system or your metabolism it like they don’t have an appreciation for that necessarily it also hasn’t made its way over into the medical field so when I get you know when I go and I present at medical conferences whether it’s at ifm or it’s at Nami or mha or any of these you know more like sort of medical conferences sometimes people know the microbiome sometimes they don’t.
Sometimes they know leaky gut sometimes they don’t sometimes it sounds completely foreign and ludicrous that you could do something at the level of the bacteria in your gut and it’s going to change your overall mood and mental function and performance like that doesn’t compute a lot of times unless you’ve been exposed to the research right.
I want to show you an a just another place where that is where that is very true so these Studies have been done so many times in mice and in rats and now in humans that it’s, I don’t want to say it’s like connect the dots that easy but it’s pretty well known like step by step by step what’s going to happen whether it’s a probiotic treatment or whether it’s a Prebiotic treatment or increasingly a post biotic treatment or aphytobiotic treatment.
I want to show you one that I hope will blow your mind if you’re not aware of this research already so this is probiotic treatment of mice with autism features so we could also cross this out and say Prebiotic treatment of mice with autism features autism is one of those systemic dysfunctions right I mentioned a few minutes ago that we have to think of the the gut brain axis the heart brain axis as a system if we want to get the best results for our clients and patients so we can intervene in the brain we can intervene in the gut we can intervene some place in between.
In the axis that’s what these studies do and autism is a really um uh I don’t want to say severe but it’s definitely a condition that has um places that can be rebalanced across that entire that system right, there’s things we can do in the brain to improve there’s things we do in the gut to improve there’s things we can do in the access to improve and we know that if we alter the microbiome that’s going to change the signals it’s going to change the Integrity of the barrier right.
Whether it’s leaky or whether it’s tight junctions um it’s as a result of that it’s going to change the metabolites that get through into the systemic circulation or into the endocannabinoid system or into the into the immune system and as a result of that it’s going to change behavior and so this has been done over and over and over again in rodents it’s been done several times in humans and so like we know exactly what’s going to happen change the microbiome improve the Integrity change the metabolic signals change the behavior.
And so these two studies were done let me see this one was in 2018 so not that long ago this one was done in 2019 2018 also um so you know just pre-pandemic which would you know good time to be studying psychology what both of these studies did was they applied a Prebiotic fiber as the intervention in children with autism the one on the top was done in the UK they used a Goss galacto oligosaccharide they actually used the brand called bimuno it’s the same one that we use in our products.
This one was done in Japan used a hydrolyzed guarg um Prebiotic fiber which is also called a galactomanc the brand they used here is called Sun fiber it’s the same brand that we use in our products I didn’t mention when I had the fundamentals pack up there we have a fundamentals pack that won the Nutra award and we have a kids fundamental so a kid’s version of that same pack that’s just one product so instead of three products it’s one product it’s naturally flavored it’s naturally sweetened no sugar tastes like fruit punch when you mix it up and said into a beverage that was a finalist for probiotic of the year that was launched which was the year after fundamentals.
So fundamentals in 2018 uh kids fundamentals in 2019 these studies coming out in 2018 and what they found was exactly what I showed you on that last slide but this was done in children give them a fiber intervention here Prebiotic fiber change the microbiome change the gut Integrity change the signals in the axis change the behavior of the kids had better sociabilityum they had less acting out they had less uh irritation they had less irritability they had less stomach aches and constipation they behaved better all because of step by step by step by step with an intervention at the level of the microbiome and the reason I make a big deal about this is not because like Isaid before like we’re not trying to treat depression we’re not trying to treat anxiety disorders we’re also not trying to treat autism but these data are out there they exist and if you have clients and if you have patients tha tare in those situations they need to know that there are natural options that they can bring to bear on the problem of feeling happier feeling less tense fearing less feeling lessirritable you know behaving better.
Those are all impactful things that we can talk about it we can say look if you want to improve your mood if you want to lower your stress if you want to improve your resilience talk about it in a very positive way but these data are out there and think about this if these research groups in the UK and in Japan um 20 years ago had tried to say hey we’re going to use Fiber as an intervention for autism behaviorsum it would have sounded absolutely completely ludicrous but that’s before we knew anything about the microbiome and now we know what the microbiome does.
We know how it impacts on gut Integrity we know how that impacts on signals going across the axis we know how those signals impact on overall feelings and behavior and performance right so it’s a really really exciting time that we can harness this kind of stuff and we can use it we can apply it to help the people that we work with you know perform their best so that’s fundamentals so a lot of times people will take those products um the two powdered products the mentibiotics which is unflavored and the kids fundamentals which is fruit punch flavored and they’ll combine it with other products like Edge is a product I’ll talk about now and another product we have called Energy Plus.
Edge & Energy Plus Health Drinks Also Known As Happyjuice
Which is our healthy energy drink product we’ve got a couple of versions of that into something that they call Happyjuice so it’s three powders people mix it all up into one uh you know one jar you know one glass and mix it up and you know sometimes they’ll throw in grape and sometimes watermelon and sometimes dragon fruit and sometimes pomegranate lime and people have all their different concoctions, and they call it happy juice because they get these benefits that I just talked about.
The resilience and the you know lowering of the negative mood States and the raising of the positive mood States but then they get motivation from Edge and they get energy from energy and a lot of people just describe that as they feel happier they feel more resilient they feel like they can get a better handle on their day. So I want to talk about some of those products, so this one Edge, when we launched this was a finalist for an award called the next D Awards so fundamentals won the neutral award uh kids fundamentals was a finalist for probiotic of the Year.
This was a finalist for the next um and this is a really cool product because it’s a non-stimulant way to increase motivation, motivation is different than energy motivation is um it’s more of an actionable kind of energy right people feel like getting up and getting something done and we do it without caffeine we do it without sugar this is sugar-free naturally flavored we’ve got a watermelon flavor we’ve got got a grape flavor.
The main active ingredients here are mango Leaf which is really high in these anti-inflammatory compounds called xanthos lychee fruit really high in polyphenols that can help with glycation or blood sugar control that’s going to be really good for your brain, it’s going to be really good for your muscles, so once you get motivated from the from the mango Leaf you’re going to be able to apply that motivation into mental work or physical work and then this last one is a palm fruit bioactives from awater-soluble fraction of the palm fruit, um and this uh this helps with oxidation it’s high in these very unique uh flavonoids called chicimic acid flavonoids um and there’s dozens of clinical trials on you know across these three uh ingredients.
One thing I should mention is that you know for health professionals or scientists or whoever’s watching this right now uh for each of our products we have a document called the technical data sheet, so the technical data sheets will go through all of the research abstracts on all the different ingredients so you can go and see well what does palm fruit do and what’s in it and how does it work, what’s its mechanisms of action and what lychee and mango Leaf right, so you can see all of those clinical studies on sports performance and cognitive performance and glucose balance and all that kind of stuff so you can see exactly what it is.
You know in the spirit of being as transparent as possible to say here’s what it is here’s what it is here’s how we’ve combined it here’s how you can combine that product with another product in terms of stacking and things like that, so in 2022 this was a finalist for best new product there were over 1100 entries that year and we made it down into the last five which was really cool for us.
Here’s how they work three patent ingredients more than 50 clinical trials you know across those um three bioactive ingredients we put it into a base of Prebiotic fiber which is really important right so you could call this a nootropic this is a brain booster this is, you know sometimes people talk about them as you know being like you know natural smart drugs and some of the NOAA Tropics out there are actual drugs you know some of them are illegal drugs that you can get on the internet but this is a natural way to do it to enhance creativity and memory and motivation and attention and all those sorts of things.
We use that same ISO fiber that isomaloligosaccharide that we use in fundamentals that I talked about before we use that same that same Prebiotic fiber here so you know it’s a drink mix right it’s one of them is grape flavored one of them is watermelon flavored um and it’s sugar-free naturally sweetened um naturally flavored all the things that you would want and it’s the Prebiotic fiber that is sort of the carrying agent if you will of these bioactives that help you know help with the things that I just said.
Here’s another little graphic showing what the mango Leaf does what the lychee fruit does what the palm fruit does and they’re sourced from around the world um there’s a little video online somewhere um that is called from The Source where I go through each one of these where they come from how we Harvest them what the extracts look like why we partnered with, you know this particular supplier versus that particular supplier so if you’reinterested in getting into the nitty-gritty on the sourcing side of where this come, where all these ingredients come from that would be a good resource for you and you can see something Nitty Gritty there.
So that’s our Edge that people will very often mix with so you can take Edge separately on its own that can be the only product you take and you’ll feel better again in quotes in those ways but those are different ways of feeling better than what I just described for fundamentals or for kids fundamentals okay so hopefully you’re getting that idea.
Here’s mental heart this is a different way of helping people feel better so fundamentals is all about the gut brain axis and those signals are primarily biochemical in nature right they’re neurotransmitters and short chain fatty acids and those sorts of things right so by changing those signals we can help people feel better. Mental heart is a nutritional approach to work on a whole nother set of signals which are electrical or electromagnetic in nature and I’ll describe those in just a second, but here are the main ingredients this is Bergamot Orange looks like a lime but it’s actually a little orange.
This is astaxanthin this is palm fruit bioactives again this I don’t know if you can see it behind my little video but this is black cumin seed oil they all work in different ways to improve heart health and heart efficiency. We also have coenzyme Q10 in here and that improves the sort of the strength of the contraction a contractile activity of the heart and you put all that together and mental heart is absolutely a heart health product but it’s also a sports performance product, it’s also a brain health product, it’s also a mood supporter.
We actually just received a patent on that on the idea that you could use a nutritional to improve heart function and as a result of that improves psychological function, cognitive function and emotions and I’ll differentiate those as we go through here okay so this idea of the heart and the Brain talking to each other we’ve known about this since at least the 1950s we’ve known that depressed patients have a high risk for a heart attack and we know that heart attack patients have a higher risk for depression.
But back in those days it was thought to be sort of Behavioral you know if you’re depressed you’re probably not taking care of yourself and that’s why you had a heart attack and if you had a heart attack you’re you know of course you’re sad because you’re in the hospital you just had this major life event of course you’re going to be depressed, and then it morphed into like the 90s it was more about inflammation and if your heart is inflamed and your brain is inflamed of course that’s going to lead to a heart attack or depression.
You know that made a lot of sense and now we know that cortisol is involved now we know that inflammation certainly is involved now we know that electrical activity is involved we can measure the rhythm of the Heart Right uh heart beats we can measure the electrical activity of the heart of the brain waves, you know so we’ll put heart rate straps on people we’ll put brain waves strap on people and we can have them watch how those signals are either out of sync with each other or in sync with each other. And when we modulate them what we’re actually trying to do with these subjects is helping them to be able to shift better out of fight or flight response into rest and digest response right.
A lot of times the problems that come for people who are prone to panic attacks and racing mind and racing heart and just feeling stressed all the time because we’re on 24 7, is because we get stuck in sympathetic Drive the sympathetic nervous system is activated and activated and activated and activated and we’re unable or inefficient at least in down shifting and shifting over into parasympathetic Drive where our bodies can recover and we can rejuvenate and we can recuperate and that’s is where you know that’s where burnout happens.
People spend too much time into in sympathetic drive and they just sort of burn themselves out and so if we can more efficiently help people shift from being on when you need to be on but then being off when you need to be off and recover and you know get good night’s sleep and things like that so that’s what this does, if we can improve the efficiency of how the heart and brain talk to each other we can improve this shifting and here’s how.
We go about measuring that and modulating that this is a study that we did uh and and presented at the American College of sports medicine’s annual scientific conference um here’s the title of the study optimization of heart brain axis signaling improves mental and physical performance and this study was actually the basis of the patent that we got so we did the study we filed the patents um and then we launched the product um after we knew the product did it did exactly what we thought that it did, and here’s the results I won’t go through all the sort of Preamble.
I’ll get right to the moral of the story free, so after 30 days of supplementation with mental heart we showed that heart rate variability was improved I’ll talk more about that on the next slide but people felt better so you know profile of mood States again right this is the gold standard way of measuring how non-diagnosed people are feeling and so negative mood states are going down, tension, depression, anger, fatigue, confusion but I want to point out something here.
Look at the dramatic numbers that we’re seeing here the depression indexes are going down 76 percent meaning their mood index their mood parameters are increasing 76 percent. Confusion which is sort of like brain fog going down 62 percent meaning their focus was improving 62 percent, really nice number more than you know more than a 50 Improvement in energy levels because fatigue indexes were going down so people were clearly feeling better.
As a result of the mental heart or what became mental heart um supplementation here are two ways of measure or calculating heart rate variability so a higher heart rate variability is better it’s better for your heart function higher heart rate variability is associated with a lower risk for heart attacks It’s associated with, so with athletes a higher heart rate variability is associated with a higher recovery index so if your heart rate variability were low we would say to that athlete you’re not fully recovered yet we want you to do a light workout today or we want you to get some more sleep.
Where we want you to you know not work out at all or you know more recovery that kind of stuff, we can use it for the same thing of judging stress load judging uh parasympathetic tone and so there’s a couple different ways you can calculate it, no matter how we calculate it it’s better after mental heart after supplementing with mental heart for 30 days. 11 in this parameter 19 in this parameter and this is also a way of looking at parasympathetic nervous system tone this is your ability to shift away from sympathetic into parasympathetic this is your ability to downshift out of drive into recover.
Out of go into slow okay so that is a really really good thing to for people to have and this is the first time it had ever been shown for a nutritional to do it we know we can do it with breath work we know we can do it with sleep we know we can do it with different recovery modalities and so here now we also have a way we can do it from a from a nutraceutical perspective here’s all the the profile of mood State sub scales have already gone through those.
Overall well-being was improved 23 percent uh with this particular supplement and the cool thing about this is that we were able to show that these improvements and heart rate variability gives you a physical heart benefit which leads to a psychological mental benefit the cycle you know the psychology parameters, but what people also had was they had a cognitive benefit I don’t have those slides here um I don’t think I have them in this whole deck but we have some other studies that we’ve done where we have shown there’s a physical performance benefit there’s an emotional performance benefit mood and there’s a cognitive performance benefit.
Things like focus and memory and executive function and problem solving and those sorts of things I think I do talk about that in one particular way with it with a different product but so you can see this has opened up a whole new field of heart brain access and we probably would publish a bunch of papers in there so we have the gut brain axis that we can modulate to help people feel better, we have the heart brain axis that we can modulate to help people feel better, and then we can and let’s not forget about the brain let’s not forget about the brain in the head there’s all kinds of things that we can do for the brain in the head.
This is one of the products that we use to bring to bear on that problem and so this product is just called mood plus, so mood plus when we launched this in 2018 this was a finalist for Botanical of the year because it has 10 Botanicals in this formula that have been used for centuries right, from all the traditional medicine system.
Traditional Chinese medicine over 3000 years, traditional Indian medicine Ayurveda, over 5000 years these are where we get the ideas for these and then we extract them in a particular way so we can standardize them so every single bottle every single capsule has the same level of efficacy, we can use the exact ingredients that were used in the clinical trials which I’m going to share with you so that we know that we get efficacy so that we know that people are going to feel better um and we can Source them from good trusted sources, so we know we get good efficacy, good Purity, good potency all that kind of stuff.
What we have in here are like among those ten you can see the whole supplement facts panel here of those ten, four of them really really stand out for their overall clinical efficacy, this is Rafuma this little purple flower up here this rafuma is here we use a brand called venetron this helps support mood, this is Kana we use a brand called zembran this helps us support resilience this is um ashwagandha we use a brand called sensorol that helps support stress or lower stress and stress hormones.
And this is uh this is Magnolia bark we use a brand called rolora that helps lower tension and also helps with stress eating so let’s go through each one of those in turn, so this is rafuma the venetron ran has been shown using this score so I use in a lot of the trials that we use when we’re studying non-depressed non-anxious non-diagnosed normal subjects people who are moderately stressed or sleep deprived or something like that.
We use profile of mood States when you’re studying someone who is depressed you will very often use this scale called The Hamilton depression index and so on this scale rafuma after four weeks reduces that depression index by about 30 percent, after eight weeks by it reduces that index by about 50 so that’s a massive massive magnitude of effect over a pretty short amount of time within herb because this is something from traditional Chinese medicine that’s been used for Millennia to treat Melancholy.
Right if you’re feeling kind of the Blues and you’re not quite happy about anything and you know that sort of depression like and so this has been studied using the Hamilton depression score to show that 30 reduction 50 reduction over time it also helps with insomnia and this is really important because very often people who are depressed will have trouble sleeping and that trouble sleeping will lead to more depression.
We see it all the time this is a vicious vicious cycle to get out of and so a lot of times these people will get an anti depression drug an antidepressant you know a Prozac or Zoloft so that they’re not feeling as depressed but that can interfere with their sleep even more sometimes they’ll also get a sleep drug to try to squash both of these and it doesn’t work very well because they just don’t feel much of anything anytime and that isn’t how they want to feel.
They want to feel better they don’t want to just feel less worse and so this is a way that you can solve both problems from a natural perspective with refuma okay so there’s that here’s Kana, so Kana is a you can see the Latin name skelitium tortuosum we cultivate so it can be wild crafted in South Africa and you can see a gentleman from the sand tribe doing exactly that but we cultivate it with a cultivation partner over there we grow it under very controlled conditions in greenhouses so we can maintain the bioactives at just the level that we want because if we’re able to do that we can get this with one dose of zembrin on a single usage.
You can see this you can see that using using functional magnetic resonance imaging FM fmri you can see that a single dose will and I’m just going to read this attenuate the reactivity within the amygdala that responds to threat and stress so when you’re in fight or flight reaction when you’re having a stress response right now in this moment and your amygdala is firing you can have somebody supplement with mood plus, and this dose of zembrin and it’ll take their stress response from a 10 let’s say down to a nine eight seven six.
It’s not going to shut it off it just attenuates it enough so that that person can function and so people generally like that effect right they like hey I was stressed out and now I’m able to get my get my work done um you know you still have the stress response so you still have the motivation you still have the fire lit under your butt so that you get the job done but it’s in a way that you’re able to function instead of freeze right um if you have them now supplement for three weeks, now you start to see this where the zembrin groups has this very significant Improvement in something called cognitive flexibility.
That is akin to being more resilient in the face of a stressful event so you can help them with the stressful event right now and then you can help them deal with the stressful event that’s coming later so, the way I describe this to people is that pre-supplementation you might have a stressful event where you just go this is terrible I can’t deal out and you will literally like you will actually back away from it but if your resilience is higher if your cognitive flexibility is higher that same exact scenario would still be stressful.
But now your resilience is high enough where you can look at that same thing and say wow this is not a good event but we’re gonna figure it out and you’ll step into it and say how are we going to solve the problem, how are we going to navigate this what decisions need to be made, that’s what cognitive flexibility is it’s decisionmaking it’s impulse control it’s strategy formation and so your cognitive flexibility or your resilience is higher after using zembrin three weeks after than it is before so that’s a really nice effect and that so mood what reformer works on is one way of feeling better resilience.
What zamarin works on is another way of feeling better you can see how what we’re doing here is trying to get people to feel more comprehensively holistically better and those are two way of doing it a third way of doing it is ashwagandha, ashwagandha is really really hot right now but uh similar to what I was talking about before when I was talking about probiotic strain specificity, you have to have the same skeptical hat on when you start talking about herbals because with ashwagandha there’s a lot of non-standardized ashwagandha powders out there that don’t have any level of potency.
You have some you know so you have some extracts out there that are Roots which if you have a good ex if you have a good ashwagandha root it might relax you if you have a good um so that’s a root extract if you have a leaf extract or a stem extract that’s going to be better not for relaxation it’s going to be better for cognitive enhancement or maybe even for energy right.
Completely different effects just because they’re coming from different parts of the plant what we use is sensoril, is a whole plant extract so we’re getting root extract stem extract leaf extract because what we’re trying to go for here is sort of a 50 50 proposition of energy and relaxation, what we would call what we refer to as being in the zone, and so that’s what we want in this particular product.
If we wanted just a relaxation product we would get a really good ashwagandha root extract that’s standardized to the to the bioactives that we’re looking for or if we wanted to focus a kind of a one we could get a different extract that’s standardized for those we want an overall balancing effect and that’s exactly what we get, so you can even see this over the course of a month of supplementation you can see that cortisol levels, primary stress hormone come down about 20 25 percent with sensoril and the counter-regulatory hormone to cortisol DHEA which is the precursor for testosterone in both men and women.
That goes up about 30 percent so when we’re stressed out cortisol levels will go up that’s generally bad and DHEA levels will also go down that’s also bad it’s really bad when you have both of those at the same time because you know then you’re going to be not just stressed and irritated but now you’re going to be moody now you’re going to be tired now you’re going to be gaining weight around the midsection and so if you can normalize both of those hormones get them both into balance you know, not just lower cortisol and not just raise DHEA but get them back into balance with each other that’s what sensorial does and that’s why we choose this one because it has that true balancing effect right.
That sort of you know you see it biochemically here but you also see it psychologically where people feel they feel sort of just like dialed right into that zone where they feel like they can get things done and then the last of the sort of main four that are in there is rolora and I said it was magnolia bark but relore is really a magnolia bark, philodendron bark combination that has been shown to help reduce tension um and so here’s profile of mood States again right, from a completely different trial where all the negative mood states are going down and then a positive mood State like Vigor was going up.
And this is it was also a four-week trial so you know again and again and again as the mental wellness company we can say well we can help you feel better in these ways with this intervention we can help you feel better in these other ways with this intervention these other ways with this other intervention, so what we’re trying to do is really surround health professionals, surround customers, surround clients and patients whoever wants to feel better, we want to surround you with different choices that you can make to say I want to feel better in that way and that way and that way and I’m okay in that way and somebody else might say, I want to feel better in that way and that way in that way but not that way right so we let people customize whatever they need.
So this product this mood Plus it works on all those four main parameters right it’s helping with your mood it’s helping with your stress it’s helping with your resilience helping with your attention and this was probably the number one product that parents asked us for their kids, right, because stressed out teenagers, stressed out middle schoolers you know all the stuff that kids go through right, kids are more stressed now than they were when we were all kids you know social media and 24 7 you know comparisons on Facebook and Instagram and Tick Tock and all that kind of stuff.
It’s tough and it was tough for my kids who are adults now um but so parents asked us for this and the downside of this formula is that none of those four ingredients that I just talked about had ever been studied in children before or teenagers before and so we really needed to go back to the drawing board and say what can we develop for kids and teens that is not this um you know, lots of parents do decide that this is the right thing for their kids but that’s apparently decision not a corporate Amari decision.
So we formulated an entire product for kids and it’s just called kids mood plus and so this is a very very different formula it uses also you know traditionally supported um uh herbs that help with mood and stress and resilience and you know all those sorts of things so things like things like holy basil and rosemary andclove and oregano and those sorts of things but we also have a very very unique saffron extract and again I don’t know if you can see this behind my little video here but there’s a beautiful picture of saffron right behind here this particular saffron is a brand called aphron that has been used in some really important clinical trials that I’ll show you on the on the next slide.
But we put this together in a really fun way for kids and teens so they’re not swallowing more capsules it’s a pixie stick right it’s a little stick pack sachet where you rip it open and you dump the powder right into your mouth, you can dump it into water if you want to but it’s formulated to be what we call a direct to mouth powder, and kids just call the pixie stick you dump it in there it tastes like sugar but it’s sugar-free it has a base of Prebiotic fiber it’s naturally sweetened.
It’s naturally flavored it tastes delicious and it does all these wonderful things it helps normalize serotonin and dopamine balances, stress hormones like cortisol supports resilience and improves all these different mood State parameters right in a fun way. This is the other product that we just received a patent on right, so we have a patent now on this blend to help with signaling across the gut brain axis to help people feel better to help them with with all these different mood State parameters, so I actually use this product myself.
I say right up here it’s not just for kids, adults, a lot of adults use it including me and it’s not just for mood because even though it’s called kids mood plus most people I think use it for Focus largely because of this study, so this study uses the ex so all of these studies use the exact saffron extract that we use in this product this safron’s been shown in this particular trial to be a equivalent to a drug called methylphenidate that’s Ritalin, that’s Ritalin and Adderall so the reason I make you aware of this is that I don’t want you to say oh here’s a here’s a replacement for Ritalin.
Here’s a replacement for Adderall um as health professionals we have a little more leeway to talk to our patients about what’s available what works how we’d like to use it, what would like to use it instead of all that kind of stuff, but you can sure as heck Amari isn’t out there saying here’s an alternative to Ritalin even though there’s data out there that shows that right, there’s some legal ramifications for that, and I have another video that explains you know how we talk about these sorts of things.
This study looked at this same safron extract in teenagers with depression and it compared favorably to Prozac this one looked at post-menopausal women and showed that safron could improve their Sleep Quality so we have something that helps with Focus something that helps with sleep qual and and so focus in children Sleep Quality in post-menopausal womenand uh and mood in teenagers right so it’s not just for mood, it’s not just for Focus, it’s not just to help you relax, it really is that overall mood enhancement and so when we put that all together we had really good data on safron.
We had really good data on holy basil and rosemary and good traditional usage for things like clove and Etc but when we put it together in our little pixie stick formulation we wanted to do a you know a little pilot study to see see how it would perform and so here’s all the main ingredients that I just talked about here’s the base that we put it in, a base of Prebiotic fiber natural sweeteners natural flavors um you know plant extracts to help it flow better and we did a little trial in 10 families and we saw 10 out of 10 of those families their kids had improvements in Focus mood and mental performance and the way that we did this one instead of using profile of mood stage which isn’t really used in children it’s really something that’s reserved for adults.
We use this other scale that was developed by the American Academy of Pediatrics and it’s very often used by clinicians to help parents judge should are these kids um candidates for ADHD medications right so we use the same you know the same the same tool we had them supplement with um with kid smood plus.
Final formulation the one the actual one that got patented for 30 days and we did a pre-supplementation and a post-supplementation value and what you showed with this particular um with this particular uh tool that we that we used you get two main outcomes. One is called an attribute and one is called a performance metric and so on this first one it measures um how are the kids doing on parameters like Focus attention mood listening tension irritation right, are the kids listening, are the kids you know doing their work, are they you know are they not acting out you know, are they not you know, irritated or anxious or you know that kind of stuff and you can see very nice effect 29 effect um 29 benefit.
So here again a kind of like Global mood State a lower number is a better number on this parameter this performance metric sometimes what you’ll see is that kids do fine here when they’re sort of like under controlled conditions when they’re in their element they’re doing great but then you put them in a stressful situation like school work math Reading Writing social relationships like being on a sports team being in a dance recital being you know some place where they’re a little bit chaotic, and what happens the wheels come off right they have a blow up, they have a meltdown but even here in those sorts of situations the kids were still better and that to me is the really really important one.
So you know two different ways of measuring this but two differentreally really nice benefits um so that shows us that we can use a completely different formulation with different bioactives that work through different Pathways to get you to the end goal, which is feeling better performing better and so they can be used like I said complementary I take mood plus every single morning to help with my resilience I take kids mood Plus almost every afternoon usually before doing a webinar like this or doing a zoom call or something to make sure that I’m sort of on task and you know I’ve got a longer fuse you know in case something is something as a potentially irritate me.
So those are our mood plus products um I want to say just a couple of words about this last product um which is our sleep plus product and\ I say it because sleep problems are without overstatement and epidemic there are so many people that are so sleep deprived and it’s one of those things that gets pushed off by a lot of the people that we work with right. They’re they’re interested in hearing about nutrition they’re interested in hearing about stress management they’re interested in hearing about exercise but sleep is that one thing where it you know it’s the end part of the day.
It’s the time I’m going to carve out to catch up on things or I’m gonna go to bed late I’m gonna get up early it people don’t I think have an appreciate Nation for how important it is for our mood for our metabolism for our ability to lose weight for just absolutely everything for our ability for our brain to clean itself for our the ability of our immune system to protect us and so sleep is really really important and we have a very unique sleep product that is non-melatonin.
I am not at all a fan of melatonin if you’re supplementing with melatonin you’re not doing yourself any favors um there’s one place melatonin is okay and that’s if you’re jet lagged use it for two or three days to help reset your circadian rhythm fine but then you have to get off of it because if you stay on it and you use it every night to help you go, to help yourself go to sleep you’re going to become dependent on it you’re going to have to take melatonin to sleep so you’re sort of locked in it’s not particularly effective.
It will give you maybe seven minutes is what the study suggest of uh longer sleep duration but it doesn’t improve sleep quality it’s definitely not something you should be using in children because it’s a hormone, it can interact with or at least it has impact on reproductive hormones so it absolutely shouldn’t be used in children or in teenagers who are going through puberty. So what’s the alternative right kids need to sleep adults need to sleep um here the alternative is to use a non-melatonin sleep enhancer which is what sleep plus is.
The main ingredient here is uh is a monocot grass called corn grass corn grass and wheat grass are in the same family called monocot grasses and those grasses are high in something called 6 mboa. I’ll show it to you on the next slide six mboa is a precursor that your body can use to make melatonin to help you with Sleep Quality or serotonin to help you with mood, so sleep plus the Sleep part, is the Sleep part, the plus part is the mood part, if you supplement with this every night you’re going to be able to make more melatonin in the night if you’re exposed to Darkness so you have better sleep quality.
You’re going to be able to make more serotonin in the day so you’re gonna have better mood and that serotonin in the day sets you up for a better night’s sleep because now you have the building block to make more melatonin and so the studies show you fall asleep faster about 33 percent you wake up fewer times per night about 30 percent uh fewer times and you have an huge Improvement in sleep efficiency and Sleep Quality 50 Improvement sleep efficiency.
40 Improvement Sleep Quality so sleep efficiency is a measurement of the amount of time that you’re in bed how much of that time are you actually a sleep, that’s sleep efficiency, Sleep Quality is the measurement of how much time you’re asleep, are you spending in the high quality parts of sleep REM where your brain recovers and deep whereyour body recovers and recuperates so if we can improve either of those sleep efficiency or Sleep Quality that means that even if you’re only getting six hours a night it’s a higher quality.
Six hours ideally we want people to get eight hours every night and high quality high efficiency but you know there’s this thing called reality where that’s not going to happen for a lot of people right so if you can get seven and it’s high quality high efficiency that’s better if you can get eight that’s even better if you can you guys get the idea and this is a way that we can do it by not giving you melatonin and instead giving you a building block for melatonin, so that your body can make the Melatonin if you need it and if you don’t need it, it’s not going to make it and that way we avoid the Melatonin hangover over.
We avoid the Melatonin where you don’t metabolize through all the melatonin and you wake up the next morning and you’re still groggy we avoid the Melatonin dependency we avoid the Melatonin impact on reproductive hormones and so we get all the all the benefits of melatonin so to speak, without the downsides and you know we’re able to sort of um work with our bodies circadian rhythms so that we start developing normal sleep cycles so we fall asleep quicker we stay asleep longer we spend more time in REM.
We spend more time in deep and the result of all of that is that you do feel better um so there are lots of studies on this showing that 6 mboa does generate more melatonin and does generate more serotonin does help with overall well-being does help with mood state does help with energy levels and so you know that’s another one that I think is really really impactful for the people who come to see us because, who comes to see a alternative-minded holistic-minded complementary medicine minded Health practitioner.
There are people who have not gotten good results with the standard offerings right maybe they’ve tried antidepressants maybe they’ve tried sleep drugs maybe they’ve tried ADHD medications, or maybe they haven’t tried those things and they don’t want to try those things because they know that all problems associated with them, so they come to us and they wanted they want a better approach they want a holistic approach they want a natural approach they want to feel comprehensively better and a lot of times I should say this a lot of times by the time they get to us they are the hard nut to crack so to speak.
They’re the ones who have tried this and it didn’t work and tried that and it didn’t work and tried that it didn’t work and so they come to us and we sometimes get the hard cases and the hard cases are the ones that need to be solved through a systems approach they need to have their whole gut brain access remodulated they need to have their whole heart brain axis made more efficient they need to have all their neurotransmitters balanced, instead of just their serotonin they you guys get the idea so we have all the products that do that we have fundamentals and we have happy juice and we have mood plus and and we have packs.
This is one of the things that we really try to do here tomorrow is help people make that choice like what is it for me that’s going to be the right set of solutions how can I feel better right now somewhat right now and then get better and better and better and better and that better and better and better and better is what I refer to as something called phased benefits. So in fundamentals pack for example there are ingredients and fundamentals that you will feel within the hour that you take them and your tension will come down and your brain will wake up a little bit right.
And you’ll feel better as a result of that but that didn’t do anything to your microbiome it didn’t do anything to your short chain fatty acid production it didn’t do anything to your gut Integrity it didn’t do anything to prime your immune system but you did feel better and you felt better because we’re able to change your brainwave activations we’re able to move you out of beta waves into Alpha Waves, so out of irritability into relaxed alertness right so great.
We can do that with certain nutrients but we that nutrient doesn’t work on some of those other things so hopefully you felt good enough where you’re going to take it the next day and the next day and the next day and after a week or so now you notice that your confusion is lifting your brain fog is Lifting and you can focus better and remember better and create better and you’re more engaged and that’s a different way of feeling better than what you felt on day one.
You can’t get the alleviation of brain fog on day one but you can get on weekone and then you like how you feel so you keep taking it and then after about two weeks you start to see that resilience come in where you can handle more stress and then after about four weeks you start to see changes in those mood indexes and those tension indexes and those resilience indexes so you feel better and then you feel more better and more better and more better and that’s just it, it’s partly related to how your biochemistry works it’s partly related to how your mood State parameters just manifest themselves and so that’s why we put together these packs.
So fundamentals pack, happy juice pack and happy hormones pack and the way I like to differentiate these is that if you have somebody that really needs to support something they have something going on, they’ve got maybe some gut issues going on maybe some you know, inflammatory balance issues going on they’ve got some memory issues going on like they have something that needs to be like, there’s something that needs to be rebalanced, fundamentals is probably the place to go because it really does adjust across that entire gut brain axis at the level of the microbiome.
At the level of the gut integrity at the level of the you know the immune system portion of your axis at the level of brain Activation so that’s a place to go if you really need to support something, if you’ve got that person that’s sort of the middle of the mental Wellness Continuum and they’re just that person that doesn’t have any problems right they don’t have any issues they’re just fine right,they’re okay um but they’re also the person that could probably benefit from a little more resilience could probably benefit from a little more sharpness in their brain could benefit from being a little happier and a little stressed out and a little more energetic, that’s the person that we want to bring from languishing up to flourishing.
From burnout up to Vigor That’s The Sweet Spot of the mental Wellness Continuum because it’s the person that looks around and goes well wait a minute I don’t have any problems and you know I am kind of fatigued in the day and I am kind of tense at night and I do have trouble relaxing and I do have trouble turning it off but so does everybody else around me, I think I’m just getting older and I think I just have a stressful job and I think I just have a busy family, well so does everybody but everybody can benefit from moving up one on that mental Wellness Continuum.
So their energy is better and their resilience is better and their mood is better that’s a happy juice candidate and these are three powders that you can just mix up in one water bottle or one glass and you drink it down and you get the benefits easy peasy, if you have somebody though who is pretty good they’re maybe higher on that mental Wellness Continuum they maybe have things pretty dialed in but they want to dial in a little bit more, maybe they’re a seven or an eight and they want to be a nine or they’re an eight or a nine and they want to be a 9.2 right, that’s the person where you can say let’s dial in your performance by dialing dialing in your sex hormones.
Your estrogen progesterone testosterone dialing in your stress hormone sand your mood hormones and your neurotransmitter something like mood plus cortisol serotonin dopamine dialing in your metabolic hormone, so you can get down to that fighting weight insulin and glucose and thyroid and probably the hottest one on the market right now glip one, you know glp 1 Agonist like ozempic and with Govi and the new one that’s going to hit the market in a couple of months uh mounjaro um and increasing your short chain fatty acids.
If you can get all of these appetite is better and blood sugar is better and Cravings are lower and fat burning is better and metabolism is enhanced so you do all of these and people are really firing on all cylinders you know so the hard part of this and I and I get this is that somebody says well what if I want to support something and I want to feel better and I want to dial in my performance right can I have all of that? well sure you certainly can do that but I don’t recommend it because you know people will hear a presentation like this and they’re like yeah I want all of that please sign me up for everything and that’s not what we’re trying to do here.
What we’re trying to do here is get somebody to figure out where their biggest pain points are right now because it might be that somebody starts with a fundamentals pack and they get all the support and everything gets balanced and their gut brain access is in better shape and then they go huhall right, I’m a lot better now than I was back there two or three or four months ago and now I want to switch over to the Happy juice and now on the happy juice I’m just doing this and I’m getting better and I’m getting better and I’m feeling good and they might move up and get to a point where they want to dial things in and they want to start training for a marathon or they want to whatever their goals are right.
So you can see whereas you get better you might change up the packs you might change up you know you well you don’t see sleep Plus on here you don’t see kids mood Plus on here we have a whole kids pack right so for kids there’s a whole kids pack that does it um you don’t see any of our other 30 or so other products right because I really wanted to focus you guys on these as health professionals I think these are the ones that make the biggest impact on the people that we work with.
It’s the easiest doorway in to get a lot of the main benefits sort of checked off for those patients so that they can feel better now and then feel more better and more better and more better with those phase benefits, so I really appreciate you guys um taking a look at this if you have any questions hit me up on my blog, hit me up on any questions go to any of the other places amari.com Amari’s Facebook pages we really really try to make this information as available and as consumable as possible so wereally appreciate you guys sticking in there and I’ll see you next time okay bye-bye.
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